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Pressure-based auditory feedback training (PBFT) from a clinically-appropriate wireless shoe insole was employed to facilitate the skill acquisition for subjects with medial knee osteoarthritis (OA). The goal of the PBFT was for subjects to learn a gait modification that targets knee load distributi...
A control optimization model predicts that an oscillating force perturbation can substantially influence the energetic cost of walking. Cost is decreased when peak ground reaction forces are aligned with positive perturbation forces (in-phase) but increased with the opposite alignment (anti-phase). ...
We explored median nerve (MN) deformation and displacement during forceful gripping to better understand injury mechanisms underlying work-related carpal tunnel syndrome. 12 participants performed a chuck grip in 3 wrist positions (15° radial deviation, 0° neutral, 30° ulnar deviation) and 2 forc...
A deep neural network is used to segment whole slide images of plantar soft tissue sections. Morphology characteristics are computed and compared in aggregate and between diabetic and non-diabetic tissue, yielding trends in the deep adipose layer septal chambers.
The mechanisms governing the attraction of biological molecules remain an open question in biophysics and chemistry, particularly in the case of actin and myosin. These molecules have characteristic lengths on the order of 10 nm, suggesting that they are subject to thermal agitation, Hamaker, and el...
Musculoskeletal models (MSKMs) can provide estimates of joint contact forces (CFs), hence enabling monitoring of joint loading. By comparing models with different levels of personalisation based on magnetic resonance images (MRI) information, we quantified how anatomical accuracy affects the estimat...
The purpose of this study is to maximize the performance of long jump in lower extremity amputees using computer simulation. A two-dimensional human body-prosthesis model was constructed, and the jump motion including approach run and prosthesis foot were optimized using genetic algorithm to maximiz...
We performed a six-month longitudinal study addressing minimal shoes versus conventional shoes as daily footwear. Focussing on peak plantar pressures and on foot metrics, we did not find significant differences between the pre and post measurements.
Tissue stiffness is an important measurement but is difficult to measure accurately. A multiple linear regression model was developed to predict exponential growth and scale parameters. Test location, location circumference, and BMI were all significant factors in predicting local tissue stiffness.
In sim approaches that integrate in vivo, in vitro, and in silico techniques to optimize healthcare strategies can accelerate medical advances. The present study shows that frontal plane in vivo knee kinematics identify those at risk for anterior cruciate ligament (ACL) injury; and, when combined wi...
Nowadays, females commonly perform Military combat roles that were once exclusively performed by males. Given the strength differences between the sexes, it is important to understand if females adapt differently to physical training, which may necessitate sex-specific training programs. This study ...
The purpose of this investigation was to quantify the mechanical response of healthy facet capsular ligaments (FCL) in a porcine model. Twenty-five porcine FCL samples were subjected to uniaxial stress-relaxation tests at 30% and 50% strain to quantify their elastic and viscoelastic properties. Resu...
Yunshou is a primary movement form of all kinds of Tai Chi, to which the meniscal stress response characteristic is not clear. This study applied finite element (FE) analysis with kinetic data to track the meniscal stress response during the typical Yunshou. The knee could flex with max angle of 58Â...
Military personnel demonstrated asymmetrical knee strength and loading during landing from different dynamic tasks. Though increased knee flexion significantly improved shock attenuation, only peak knee flexion on the non-dominant limb during a single leg drop landing correlated to knee extension st...
We measured the recruitment threshold and discharge rate of m. flexor hallucis brevis (FHB) motor units during a maximal voluntary contraction (MVC) using indwelling fine-wire electrodes. We observed motor unit recruitment across a wide range of isometric forces as well as across a wide range of fir...
Foot placement is critical to balance control and is largely performed by muscles. Although gluteus medius activity has been associated with mediolateral (ML) foot placement, it is unknown how other muscles contribute to ML as well as anteroposterior (AP) foot placement. This study investigated musc...
Use of passive exoskeletons to tune muscle-tendon dynamics for improvement of balance remains an unexplored area of research. A computational model of standing balance on a passive prosthesis was used to find values of hip exoskeleton stiffness and damping which optimized resistance to destabilizing...
Electrical vestibular stimulation (EVS) can be used to manipulate the vestibular input to the medial gastrocnemius muscle (MG). The aims of this study were: 1) to identify the lowest noisy EVS amplitude that results in modulation of MG activity; 2) to identify whether a motor unit response to EVS is...
Predictive simulations have the potential to support personalized medicine, but detailed musculoskeletal models come with large computational costs that limit their use. We have developed a computationally efficient framework to predict human gaits based on optimization of a performance criterion. O...
In the last two decades, quantitative magnetic resonance imaging (qMRI) has grown into a powerful tool for exploring in-vivo biomechanical and functional properties of the musculoskeletal system. However, most qMRI methods are developed and maintained in-house, which results in a lack of transparent...
Most running studies are conducted in laboratories and lack ecologic validity. Purpose 1. compare landing impacts between footstrike patterns (FSPs) during a marathon and 2. assess the relationship between speed and landing impacts across FSPs. Methods: Tibial shock of 226 M+F individuals (44.3±1...
The stretch-shortening cycle is a naturally occurring muscle-tendon function that serves to potently enhance performance, and when implemented until exhaustion results in neuromuscular fatigue that differs from that induced solely by isolated contractions. Comparable with previous reports with soleu...
Existing literature has established kinematic and kinetic differences between treadmill and overground running. This study sought to investigate how metatarsophalangeal joint (MTPJ) mechanics differ between the two conditions. Range of motion, peak moment, and joint stiffness of the MTPJ were signif...
The goal of this research is to evaluate the effects of the Mobility Enhancing Device for Sit-To-Stand (MEDSTS); a sit-to-stand assist exoskeleton that is under development as part of this research investigation. The MEDSTS mimics the human system through the use of artificial tendons, on human loco...
There is a gap between the understanding of the mechanisms of sporting injury and the ability to monitor these risk parameters during a game. A single-sensor wearable solution which could be used in lieu of captive laboratory biomechanical instrumentation would be a breakthrough for accurate and val...
Musculoskeletal spine models are entirely based on data from adults and might not be applicable for children and adolescents. We therefore created spine models for each year from 6-18 years of age by adjusting length and mass distribution as well as inertial properties, sagittal alignment and muscle...
The current work encompassed the development of a multi-directional CT-compatible mechanical testing device and quantified the accuracy of full-field displacements predicted by QCT-FEMs of the scapula. Digital volume correlation (DVC) was used to derive full-field experimental displacement measureme...
There is a gap between the understanding of the mechanisms of sporting injury and the ability to monitor these risk parameters during a game. A wearable solution in place of captive laboratory biomechanical instrumentation would be a breakthrough for ecological validity and facilitate on-field monit...
Equine third metacarpal (MC3) bones experience a range of surface strains which are a measure of displacement induced by mechanical loading. It is, therefore, desirable to develop an efficient, yet accurate, model in which the mechanical loading of MC3 is obtained via the induced displacement and st...
Real-time sonified biofeedback has the potential to facilitate skill acquisition related to balance and successful turns. Turning is an essential skill for dancers and pedestrians. However, in order to turn, people must achieve conflicting mechanical objectives. Specifically, people need to concurre...
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