Abstract Summary
Mechanical loading plays an important role in maintaining normal cartilage health. On the other hand, abnormal mechanical loading potentially results in cartilage degeneration. However, there is limited data quantifying the in vivo cartilage mechanical strain response during activities of daily living. This talk will discuss a novel in vivo “stress test” utilizing MR imaging to quantify cartilage strain in response to different durations of walking. Additionally, applications of this technique will be presented for those at high risk of cartilage degeneration. These data provide important benchmarks for healthy articular cartilage behavior during walking and provide a baseline for studies investigating the influence of exercise on cartilage health.