Abstract Summary
Obesity is a risk factor for the development of knee osteoarthritis. While numerous studies have hypothesized that the primary pathological stimulus is increased joint loading resulting from elevated body mass, there are limited data on the effects of obesity on local in vivo strain distributions in knee cartilage. Furthermore, disruptions to the composition and organization of the cartilage extracellular matrix associated with obesity may alter the mechanical response of cartilage to load. Thus, this talk will utilize novel combinations of MR imaging and 3D modelling to explore the relationships between obesity, altered cartilage strains, and cartilage composition.
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