Abstract Summary
Carpal tunnel syndrome is caused by compression of the median nerve in the carpal tunnel. Division of the transverse carpal ligament is a routine surgical procedure to treat the hand problem. We have developed alternative biomechanical approaches to carpal arch space augmentation by radioulnar wrist compression and interaction between the thenar muscles and transverse carpal ligament. Our studies have demonstrated the effectiveness of these biomechanical methods in increasing carpal arch area, reduction of nerve flattening, improvement of nerve function and hand symptoms in patients with carpal tunnel syndrome. We illustrate that biomechanical properties of the carpal tunnel can be harnessed as non-invasive treatment options for carpal tunnel syndrome.