Abstract Summary
High-speed biplanar videoradiography (HSBV) enables new insights on the in-vivo dynamic motions of the pathological spine. Variations in the defined segment specific anatomical coordinate systems (ACS) likely influence repeatability of vertebral kinematics. This study investigated the effects of repeated vertebral ACS definitions on the resultant cervical spine motions measured with HSBV. The range of differences in angular rotations informs the minimum detectable change values for use in longitudinal studies and clinical interpretation.