Abstract Summary
This investigation explored the geometrical customisation of the established BOX total ankle replacement (TAR), to minimise the critical issue of prosthesis-bone size mismatch. A customisation procedure was developed and applied in eight patient-specific bone models through in silico implantation. These implantations were used in a comparative analysis to investigate the effectiveness and quality of customisation. This was successfully achieved with initial positive results of improved implant seat, worthy of further investigation.