Abstract Summary
Owning to sufficient stiffness at room temperature, rapid shape memory ability when exposed to body temperature, in vivo stability and soft nature to matching the mechanical properties of soft tissue, poly(glycerol-dodecanoate) (PGD) is a promising biodegradable polymer which could be applied as soft tissue replacement. Our purpose is to fabricate a body temperature triggered micro-coil plugs which could be delivered through minimally invasive device to fill and maintain the height of the degraded nucleus pulposus. In this study, we focus on tailoring the glass transition temperature and mechanical properties of PGD through curing conditions. The results showed that transition temperature of PGD decreased as the increasing of curing time. Besides, curing velocity of the purified prepolymer was faster than the raw material. Thus, we can tailor the transition temperature and mechanical properties of PGD to the proper region through curing duration to fulfil our purpose.
Sign in to ORCID