Finite element analysis for effects of clinical infusion plan of paclitaxel on hyper-elasticity of living pc-12 cells

Chemotherapy treatment of cancers by paclitaxel often results in peripheral neuropathy which is the main reason for patients to withdraw from the therapy. The function of a peripheral nerve depends highly on biomechanical properties of its tissues and cells. The goal of this study is to investigate the alteration of biomechanical properties of autonomic neurons affected by pharmacokinetics of two paclitaxel dosing schedules by atomic force microscopy (AFM) and the finite element (FE) method.