Abstract Summary
The implant failure for large defects is usually induced by unfavorable stress distribution due to unsuitable structural design in mandible reconstruction. Topology optimization is usually applied to solve structural optimization under one loading condition and cannot be applied to a specific mandible region with multi-occlusal forces. In the developed weighting topology optimization method combined with finite element analysis for large defect mandible reconstruction, unnecessary material can be removed to avoid implant failure resulting from excessive weight and the mandibular implant can be strengthened enough to withstand the complex occlusal loads.