Abstract Summary
A systematic review of the murine tibia axial compression model was carried out in order to explore the effect of static preload (SPL) on bone adaptation. SPL is a recently identified potential inhibitor of loading-induced bone adaptation [1]. Of 1766 initially identified references, 15 articles met the inclusion criteria and were selected for meta-analysis. While meta-regressions did not directly indicate that SPL moderated bone adaptation, data trends suggested that greater levels of SPL alter the anabolic response of bone to dynamic loading. This study therefore supports the need for further investigation of the effect of SPL as a variable that confounds associations between bone anabolism and dynamic loading.
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