Abstract Summary
Rat femur fracture models are widely used in small animal proof of concept research. The objective of this study is to determine whether a significant difference exists between femoral 3-point bending strength of male Sprague Dawley (SD) and female Wistar rats as well as between Wistar rats of different ages. Findings show a 10% difference in shaft widths and 26% in ultimate stress between strains and suggest data between these strains of rat cannot safely be cross-referenced. Measurements of Wistars show an increase in femur size and stiffness, as well as a decrease in ultimate stress with age, indicating that age of rats is an important factor to control.
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