Abstract Summary
A multiscale model of the lumbar spine was developed to characterize the link between whole-body and tissue-level biomechanics for people with and without a transtibial amputation during sit-to-stand. Lumbar spine kinematics predicted trends in tissue loads well for annulus fibrosis stress vs. flexion. However, for other predictions, trends only existed for individual participants. These results indicate that while certain tissue mechanics are predicted well based on spinal motion, other metrics require use of the multiscale model to understand individual tissue-level load transfer.
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