People with uni-lateral transtibial amputation adopt an asymmetrical neural control strategy after chronic exposure to asymmetrical biomechanics

We used a novel prosthosis to simulate the biomechanics of cycling with a uni-lateral amputation in people without an amputation. This provided a model for acute adaptation to the asymmetrical biomechanics associated with using a transtibial prosthesis. We compared joint moment data to a group of people with transtibial amputation that have chronically adapted to their asymmetrical human/prosthesis system. We used this novel paradigm to demonstrate neural control asymmetries in people with uni-lateral amputation.