High resolution synchrotron microtomography strain measurement of native intervertebral disc

We have previously shown that volumetric imaging of native intervertebral disc (IVD) is possible using synchrotron x-ray microtomography (sCT) [1]. Subsequently, we have imaged an intact disc under sequential compression for structural deformation characterisation and strain measurement. Our latest imaging results are greatly improved through experimental setup refinement and reconstruction, resolving whole disc microstructure, including cells. Strain transfer was measured in different regions, including degeneration-prone posterior-lateral. Further to these technical advances, the application of these methods has potential to predict mechanical causes of degeneration and provide benchmarks for future regenerative strategies.¶ [1] Disney CM et al. (2017) Sci. Rep., 7(1), p. 16279.